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Related Experiment Videos

Simple method of assessing splenic function in coeliac disease

G R Corazza, A W Bullen, R Hall

    Clinical Science (London, England : 1979)
    |January 1, 1981
    PubMed
    Summary

    Counting pitted erythrocytes in blood is a simple, radiation-free method to detect splenic hypofunction in coeliac disease patients. Higher percentages indicate reduced spleen function, potentially linked to untreated disease duration.

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    Area of Science:

    • Hematology
    • Gastroenterology
    • Nuclear Medicine

    Background:

    • Splenic function is crucial for erythrocyte processing.
    • Coeliac disease and dermatitis herpetiformis can affect splenic function.
    • Assessing splenic function non-invasively is clinically valuable.

    Purpose of the Study:

    • To evaluate 'pitted erythrocytes' as a marker for splenic hypofunction.
    • To correlate 'pitted erythrocyte' counts with established measures of splenic function and size.
    • To assess the utility of 'pitted erythrocyte' counting in coeliac disease management.

    Main Methods:

    • Erythrocytes with membrane abnormalities ('pitted erythrocytes') were counted in blood samples.
    • Comparison with 99mTc-labelled heat-damaged erythrocyte clearance and splenic scintiscans.

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  • Analysis included patients with treated coeliac disease, dermatitis herpetiformis, controls, and post-splenectomy patients.

    • Main Results:

    • A significant correlation was found between 'pitted erythrocyte' percentage and splenic function/size measurements.
    • Elevated 'pitted erythrocyte' percentages indicated splenic hypofunction.
    • In coeliac patients, higher 'pitted erythrocyte' counts correlated with later gluten-free diet initiation and potentially longer untreated disease duration.

    Conclusions:

    • 'Pitted erythrocyte' counting is a simple, sensitive, and safe method for assessing splenic hypofunction in treated coeliac disease.
    • This technique avoids radiation exposure and is repeatable across all age groups.
    • Splenic hypofunction in coeliac patients may be associated with the duration of untreated disease.