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Related Experiment Videos

A new non-hormonal pregnancy-terminating agent

G Galliani, A Assandri, L Gallico

    Contraception
    |February 1, 1981
    PubMed
    Summary

    DL 111-IT, a novel non-hormonal antifertility agent, effectively terminates pregnancy in multiple species. Its action targets the utero-placental complex, requiring sustained availability for conceptus resorption or expulsion.

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    Area of Science:

    • Pharmacology
    • Reproductive Biology
    • Toxicology

    Background:

    • A new class of non-hormonal antifertility agents has been developed.
    • DL 111-IT is a compound belonging to this new class.

    Purpose of the Study:

    • To evaluate the antifertility effects of DL 111-IT.
    • To determine the optimal conditions for its administration and understand its mechanism of action.

    Main Methods:

    • DL 111-IT was administered via subcutaneous, intramuscular, intravaginal, and oral routes in pregnant rats, mice, hamsters, and dogs.
    • Dose-activity, time-course, and route-dependency studies were conducted.
    • Mechanism of action was investigated by examining plasma progesterone levels and effects in hormonally manipulated animals.

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    Main Results:

    • DL 111-IT effectively terminated pregnancy across all tested species and routes, with greatest efficacy in the early post-implantation period.
    • Parenteral administration in an oily vehicle over 2-5 days showed high activity (ED50: 0.04-0.7 mg/kg/day).
    • The compound acts on the utero-placental complex, causing conceptus degeneration and resorption, independent of luteolysis, pituitary, ovaries, or adrenals.

    Conclusions:

    • DL 111-IT is a potent non-hormonal antifertility agent with a novel mechanism of action targeting the utero-placental complex.
    • Its efficacy is dependent on dose, vehicle, route, and timing of administration.
    • Sustained availability of the active principle is crucial for its antifertility effect.