Effects of PTZ-induced generalized epilepsy on intestinal activity in cats

Simultaneous recordings of the EEG, the electromyogram of the small intestine, the electrocardiogram, and femoral arterial pressure were monitored in 24 cats anesthetized with halothane, immobilized with gallamine, and artificially respirated. During pentylenetetrazol-induced generalized seizures, intestinal activity was blocked, as demonstrated by the disappearance of spikes from the EMG. This block was abolished by spinal cord section at C1-C2 level and partially abolished by bilateral adrenalectomy. These results demonstrate the existence of inhibitory sympathetic mechanisms during generalized experimental seizures.