Partial remission of hyperprolactinemic amenorrhea after bromocriptine-induced pregnancy

Clinical and/or biological improvement has been observed in 7 out of 17 patients with hyperprolactinemic amenorrhea followed for 6-15 months after the successful outcome of bromocriptine (Parlodel, Sandoz)- induced pregnancy. The ovulatory cycle was resumed in 2 out of these 7 patients (with subsequent spontaneous conception in 1); in 3 others the medroxyprogesterone acetate test became positive. In all cases, post-partum prolactin values were considerably reduced. The possible causes of this improvement are discussed, examining the present data and those in the literature. Regressive lesions, due for example to vascularization defects or hemorrhage occurring in the prolactin-secreting tissue, as a result of the hyperplastic stimulus of estrogens during pregnancy, are suggested as a possible explanation.