Mass-analyzed ion kinetic energy (MIKE) spectrometry and the direct analysis of coca

The technique of mass-analyzed ion kinetic energy (MIKE) spectrometry is briefly reviewed. The direct analysis, without need of prior extraction or chromatographic purification, of cocaine and cinnamoylcocaine in coca plant tissues has been accomplished with this new technique. Detection limits of below 1 ng, with a quantitative accuracy of +/- 30% at the nanogram level, have been demonstrated.