Humoral immune response in rats with lesions of the septal forebrain area

Rats with bilateral electrolytic lesions of the septal forebrain area produced antibodies in higher titres after immunization with antigen. Similarly, the dynamics of antibody production was higher than in control rats with sham lesions. The observed effect may be connected with activation of the hypothalamo-hypophyseo-adrenal system caused by abolition of the inhibitory influence of the septal forebrain area on the hypothalamus.