[Direct and induced lymphocytotoxicity to rabbit hepatocytes in chronic active hepatitis]
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The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
Published on: February 3, 2012
Abstract:
The lymphocytotoxicity to rabbit hepatocytes either direct or serum induced was evaluated in chronic active hepatitis (CAH). We obtained the following results: a) the direct lymphocytotoxicity obtained in CAH patients significantly correlated with the cytotoxicity induced by CAH sera in normal lymphocytes; b) no difference could be recorded in CAH HBsAG positive or negative; c) the target antigen of the immune reaction seems to be the liver specific lipoprotein.

