[Penetration of amoxicillin into the cerebrospinal fluid]

The results of a study of the CSF concentration of i.v. amoxicillin in control subjects free of meningeal inflammation are presented. The drug proved capable of passing the blood-brain barrier when employed in sufficiently high doses, even in the absence of meningeal inflammation. The CSF level of the antibiotic was higher than the MIC required for most of the meningeal pathogens.