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High colloidal uptake in axillary nodes with metastatic disease
The British Journal of Surgery
|July 1, 1981
Summary
Axillary lymphoscintigraphy using 99Tcm antimony sulphide colloid is unreliable for detecting breast cancer metastasis in lymph nodes. Meticulous histological correlation is crucial for any future clinical application of lymphoscintigraphy.
Area of Science:
- Oncology
- Nuclear Medicine
- Surgical Pathology
Background:
- Accurate staging of breast cancer is crucial for effective treatment planning.
- Regional lymph node status significantly impacts prognosis and treatment decisions.
- Axillary lymph node assessment is a key component of breast cancer staging.
Purpose of the Study:
- To evaluate the diagnostic accuracy of axillary lymphoscintigraphy using 99Tcm antimony sulphide colloid in patients with suspected breast cancer.
- To correlate lymphoscintigraphy findings with histological examination of axillary lymph nodes.
Main Methods:
- Axillary lymphoscintigraphy was performed in 29 patients with suspected breast cancer.
- The radiotracer used was 99Tcm antimony sulphide colloid.
- Findings were compared with histopathological results of excised axillary lymph nodes.
Main Results:
- Of 23 patients with confirmed breast cancer, 19 had axillary lymph node metastases.
- Lymphoscintigraphy showed diminished uptake in 10 patients, equal uptake in 5, and increased uptake in 4 patients on the side of the lesion.
- Tumor infiltration was observed in some nodes with increased radiotracer uptake.
Conclusions:
- Axillary lymphoscintigraphy with 99Tcm antimony sulphide colloid is not a reliable method for detecting metastatic breast cancer in regional lymph nodes.
- Further studies require more rigorous histological correlation to establish the clinical value of lymphoscintigraphy agents.
