Consecutive intravenous infusions: simulation of two compartment pharmacokinetic drugs

A program is presented to simulate the blood concentrations which result from multiple, consecutive, constant rate intravenous infusions of drugs displaying two compartment kinetics. The program utilizes the principle of superposition and was developed for a Hewlett-Packard model 97 programmable calculator. The program can handle form 1-8 consecutive infusions, each with its own infusion rate and duration. Post-infusion blood concentrations can also be readily obtained A modification of the main program is also presented which enables the stimulation of blood concentration--time data pairs without operator assistance. A desired increment of time specified, and the program will provide concentration--time data pairs between specified starting and ending times.