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Related Experiment Videos

A morphological study of delayed muscle soreness

J Fridén, M Sjöström, B Ekblom

    Experientia
    |May 15, 1981
    PubMed
    Summary

    Delayed muscle soreness after exercise is linked to subcellular damage in muscle fibers, specifically affecting the Z-bands. This indicates that the muscle

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    Area of Science:

    • Exercise physiology
    • Muscle biology
    • Cellular pathology

    Background:

    • Exercise-induced muscle damage (EIMD) is a common phenomenon.
    • Delayed onset muscle soreness (DOMS) is a hallmark symptom of EIMD.
    • The underlying cellular mechanisms of DOMS require further elucidation.

    Purpose of the Study:

    • To investigate the morphological changes in muscle fibers following exercise-induced muscle soreness.
    • To identify subcellular alterations contributing to DOMS.

    Main Methods:

    • Muscle biopsies were obtained from the soleus muscle up to 1 week post-intense exercise.
    • Morphological analysis was performed on the biopsied muscle tissue.
    • Histological examination focused on identifying signs of tissue injury and fiber disruption at both tissue and subcellular levels.

    Main Results:

    • No evidence of ischemic tissue injury or gross mechanical fiber disruption was observed.
    • Frequent myofibrillar disturbances were noted at the subcellular level.
    • Specific alterations were particularly prominent in the Z-bands within the muscle fibers.

    Conclusions:

    • DOMS is associated with subcellular damage to the muscle contractile machinery.
    • Z-band alterations suggest localized disruption of the sarcomeric structure.
    • Overloaded muscle fibers may experience partial distortion of their contractile apparatus following strenuous exercise.

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