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Updated: Aug 8, 2026

HPLC Measurement of the DNA Oxidation Biomarker, 8-oxo-7,8-dihydro-2’-deoxyguanosine, in Cultured Cells and Animal Tissues
Published on: August 1, 2015
Oxidative degradation of 6-selenoguanosine in aqueous solutions
Abstract:
The degradation of 6-selenoguanosine (NSC 137679) (I) in water and in various buffer systems was investigated. Drug degradation in aqueous media was monitored by high-pressure of I in various chromatography. Some kinetic aspects of the degradation of I in various buffer systems at 25 degrees also were studied spectrophotometrically. The degradation, which requires oxygen, involves autoxidation of I to the corresponding diselenide, which produces a selenide and metallic selenium in the presence of oxygen. This degradation pathway differs from that reported fro the oxidation of related thio compounds.
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