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[Clinical results of cefadroxil in pediatric field (author's transl)]
Insights
Cefadroxil showed high clinical efficacy (92.9%) in children with bacterial infections. While some microbial substitution occurred, it was effective against Haemophilus influenzae with minimal side effects like mild diarrhea.
Area of Science:
- Pediatric infectious diseases
- Pharmacology and therapeutics
- Microbiology
Context:
- Antibiotic resistance is a growing concern in pediatric infections.
- Cefadroxil is a cephalosporin antibiotic used to treat bacterial infections.
- Evaluating the efficacy and safety of cefadroxil in children is crucial.
Purpose:
- To assess the clinical and bacteriological efficacy of cefadroxil in children.
- To investigate the occurrence of microbial substitution and side effects.
- To determine the effectiveness of cefadroxil against Haemophilus influenzae.
Summary:
- Cefadroxil (50 mg/kg/day) was administered to 113 children with suspected bacterial infections.
- Clinical efficacy was observed in 92.9% of cases.
- Bacteriological efficacy was achieved in 48.8% of cultured cases, with notable success against Haemophilus influenzae.
- Microbial substitution was observed in 29.3% of cases, with Haemophilus influenzae emerging in 58.3% of these.
- Mild diarrhea was the only reported side effect in 2 cases.
Impact:
- Cefadroxil demonstrates significant clinical effectiveness in treating pediatric bacterial infections.
- The study highlights the need for monitoring microbial substitution during antibiotic therapy.
- Cefadroxil appears to be a safe and effective option for acute respiratory tract infections caused by Haemophilus influenzae.
Abstract:
Cefadroxil was administered at a daily dose of 50 mg/kg in 113 children including acute respiratory tract infections suspected to be a bacterial infection and other febrile diseases. Among 41 cases in which pharyngeal culture was made twice before and after administration or urine and feces cultures were made, 20 cases (48.8%) were good bacteriologically, 5 cases (12.2%) were poor, and 16 cases (39.0%) were unknown. Clinical efficacy was obtained in 105 cases (92.9%) out of 113 cases. Microbial substitution was noticed in 12 cases (29.3%) out of the cases of which pharyngeal culture was made after cefadroxil administration. Haemophilus influenzae was detected newly after the administration in 7 cases (58.3%) out of these 12 cases. Bacteriological efficacy was obtained in 5 cases of acute respiratory tract infection of which pathogen was considered to be Haemophilus influenzae. No microbial substitution was noticed in these 5 cases. As to the side effects of cefadroxil administration, only a slight diarrhea was observed in 2 cases.