Cryptococcal meningitis: treatment of three patients with miconazole

Three patients with cryptococcal meningitis who were treated with miconazole are reported. All patients had previously received combination therapy with amphotericin B and flucytosine which was unsuccessful. All patients showed clinical improvement, and one obtained a mycological remission. Miconazole was well tolerated, and would appear to be a relatively non-toxic and effective drug in the treatment of cryptococcal meningitis which is refractory to conventional chemotherapy.