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A facile and regiospecific preparation of 6-alkyluridines
Nucleic Acids Symposium Series
|January 1, 1980
Abstract:
2',3'-O-Isopropylideneuridine, upon lithiation and subsequent alkylation, was transformed to 6-alkyl derivatives in a regiospecific manner. After acidic treatment of the acetonides, 6-alkyluridines (methyl, ethyl, propyl, isopropyl, butyl, secbutyl, and hexan-3-yl) were obtained. 5'-Deoxy-6-alkyluridines (methyl, ethyl, and isopropyl) were also prepared by the same route from 5'-deoxy-2',3'-O-isopropylideneuridine.