Secondary hematological changes mimicking the preleukemic syndrome. Report of two cases

Two women with hematological and clinical features typical of the preleukemic syndrome, including low marrow myeloid colony and cluster formation in vitro, showed unexplained spontaneous improvement with normalization of both peripheral blood values and in vitro cloning efficiency after 2-4 years. One patient had and the other developed later an autoimmune disorder. It is therefore suggested that secondary hematopoietic changes might have mimicked the preleukemic syndrome.