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Alpha-adrenergic blockers in prostatism

P F Boreham, P Braithwaite, P Milewski

    The British Journal of Surgery
    |October 1, 1977
    PubMed
    Summary
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    Alpha-adrenergic blocking agents were trialed in 30 men before prostatectomy. While many experienced side effects, a significant number reported symptom improvement and 10 showed urodynamic benefits.

    Area of Science:

    • Urology
    • Pharmacology

    Background:

    • Prostatectomy is a common procedure for men with prostate conditions.
    • Cardiovascular health is a critical consideration in surgical patients.

    Purpose of the Study:

    • To evaluate the efficacy and tolerability of alpha-adrenergic blocking agents in patients undergoing prostatectomy.
    • To assess the impact of these agents on lower urinary tract symptoms and urodynamic parameters.

    Main Methods:

    • Thirty male patients with no prior cardiovascular disease history awaiting prostatectomy were enrolled.
    • Alpha-adrenergic blocking agents were administered, and patient outcomes were monitored.
    • Twenty-seven patients completed the trial, with data collected on side effects and symptom improvement.

    Main Results:

    Related Experiment Videos

    • Nineteen out of 27 completers (70.4%) reported experiencing unpleasant side effects.
    • Eighteen completers (66.7%) reported subjective improvement in their symptoms.
    • Ten completers (37.0%) demonstrated objective urodynamic improvement.

    Conclusions:

    • Alpha-adrenergic blocking agents may offer symptomatic and urodynamic benefits for men awaiting prostatectomy.
    • The potential for side effects necessitates careful patient selection and monitoring.
    • Further research is warranted to optimize the use of these agents in this patient population.