Strain and sex dependent sensitivity to skin anaphylactic reactions in the mouse

The strain-dependent variation in sensitivity of mouse skin to passive cutaneous anaphylaxis (PCA) was observed. The results showed that this variation is not connected either with mast cell number and histamine content in the skin of different mouse strains or with the concentration of non-specific IgE on skin mast cells of these strains. Thus, other factors determining the susceptibility of mouse strains to PCA must exist.