[Hemodynamic modifications induced by volatile anesthetics halothane, penthrane, ethrane) I. Cardiovascular effects]

We had intended to reckon quantitatively the effects of volatile anaesthetics(Halothane, Ethrane, methoxyflurane or Penthrane) upon cardiovascular system of healthy young mongrel dogs, 5-8 days interval each other. After administration of a Halothane and Penthrane, heart rate(HR) increases of about 30%; blood pressure(BP) is decreasing of same percentage. Halothane causes a slight increase upon pulmonary arterial pressure(PAP), while pulmonary arterial flow(PAF) reaches 40% more than control values. Penthrane decreases of 30% PAP and of about 40% PAF. Ethranic anaesthesia produces a slight fall on HR and BP, while PAP doesn't result significatively modified; a marked decrease(40%) is observed on PAF. Aortic flow(AF) is diminished(from 20 to 30%) by administration of these anaesthetics.

Halothane causes very significative modifications on circulation, less modifications are produced by Penthrane, while Ethrane doesn't produce any changes.