Transepidermal chloride flux through hydrated skin: combination chloride electrode

A combination chloride electrode was used to determine quantitatively the outward rate of epidermal chloride transport in vivo. Regional anatomical variation and the effects of topical agents and cellophane tape strippings on the rate of chloride diffusion were determined. Transepidermal chloride flux through hydrated skin appears to be an alternative method for determining stratum corneum function in vivo.