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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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Skin absorption through atopic dermatitis skin: a systematic review.

A-S Halling-Overgaard1,2, S Kezic3, I Jakasa4

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Patients with atopic dermatitis (AD) show significantly higher skin absorption of topical substances. This increased absorption highlights potential risks of contact allergy and systemic exposure to chemicals in AD patients.

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Area of Science:

  • Dermatology
  • Pharmacokinetics
  • Toxicology

Background:

  • Atopic dermatitis (AD) is characterized by impaired skin barrier function.
  • AD patients frequently use emollients and topical anti-inflammatory drugs.
  • This usage increases risk for contact allergy and systemic chemical exposure.

Purpose of the Study:

  • To systematically review studies on skin absorption in AD patients.
  • To compare skin absorption in AD patients versus healthy controls and animal models.
  • To assess systemic exposure risks to chemicals in topical preparations for AD.

Main Methods:

  • Systematic literature search for studies on skin absorption of penetrants and drugs.
  • Inclusion of human studies (model penetrants, AD drugs) and animal studies.
  • Analysis of dermatopharmacokinetic data in patients with AD.

Main Results:

  • Identified 40 relevant articles (11 model penetrants, 26 AD drugs, 3 animal studies).
  • Patients with AD exhibited nearly twofold increased skin absorption compared to healthy controls.
  • Evidence suggests higher systemic exposure to chemicals in AD patients.

Conclusions:

  • Atopic dermatitis significantly enhances skin absorption of topical agents.
  • Further epidemiological and dermatopharmacokinetic studies are needed.
  • Quantifying systemic chemical exposure in AD patients requires more research.