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Pre-asthma: a useful concept for prevention and disease-modification? A EUFOREA paper. Part 1-allergic asthma

G K Scadding1,2, M McDonald3, V Backer4

  • 1Department of Allergy & Rhinology, Royal National ENT Hospital, London, United Kingdom.

Frontiers in Allergy
|February 14, 2024
PubMed

Insights

This study explores asthma prevention strategies, proposing a "pre-asthma" state for early intervention. Identifying and treating pre-asthma could reduce the global burden of this chronic respiratory disease.

Area of Science:

  • Allergy and immunology
  • Public health
  • Preventive medicine

Background:

  • Asthma affects 300 million globally, causing significant disability and mortality.
  • While diagnosis and treatment are established, asthma prevention remains under-researched.
  • Analogous to pre-diabetes, a pre-asthma state could enable early intervention.

Purpose of the Study:

  • To explore population-level asthma prevention strategies.
  • To investigate the potential for defining and identifying a pre-asthma state.
  • To assess if intensive treatment of pre-asthma can prevent progression to full asthma, focusing on allergic asthma.

Main Methods:

  • Literature review on asthma prevention and pre-disease states.
  • Conceptual framework development for pre-asthma.
  • Analysis of existing data on allergic asthma progression.

Main Results:

  • Asthma prevention is a neglected area compared to treatment.
  • A pre-asthma state is theoretically plausible, analogous to pre-diabetes.
  • Early intervention in pre-asthma may reduce asthma incidence and severity.

Conclusions:

  • Developing a pre-asthma state is a promising avenue for asthma prevention.
  • Further research is needed to define diagnostic criteria and effective interventions for pre-asthma.
  • Focusing on allergic asthma provides a specific target for initial prevention research.

Keywords:
asthmaasthma natural historypre-asthmapredispositionquality of liferisk factors

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