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Related Experiment Videos

Diffusion of oxygen through the mouse ear

N T Evans, P F Naylor, G Rowlinson

    The British Journal of Dermatology
    |July 1, 1981
    PubMed
    Summary

    The mouse ear

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    Area of Science:

    • Physiology
    • Biophysics

    Background:

    • Understanding oxygen diffusion is crucial for various physiological processes.
    • The mouse ear serves as a model for studying oxygen transport in biological tissues.

    Purpose of the Study:

    • To quantify oxygen diffusion across the mouse ear.
    • To identify the primary barriers to oxygen transport.
    • To model oxygen diffusion using experimental data.

    Main Methods:

    • Polarographic measurements of oxygen tension under conditions of no blood flow.
    • Experiments involving splitting the ear and removing the stratum corneum.
    • Application of a multi-layer diffusion model.

    Main Results:

    • The stratum corneum is the main barrier to oxygen diffusion, with a permeability of 1.2 X 10^-8 ml O2 atm^-1 cm^-1 S^-1.
    • The permeability of the rest of the ear tissue is 4.7 X 10^-7 ml O2 atm^-1 cm^-1 S^-1.
    • Inhibiting tissue respiration or cooling the ear significantly reduced oxygen gradients.

    Conclusions:

    • The stratum corneum significantly impedes oxygen diffusion in the mouse ear.
    • A multi-layer diffusion model effectively describes oxygen transport.
    • Factors like tissue respiration and temperature influence oxygen gradients.

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