[Blood plasma lipoproteins microviscosity and risk of ischemic heart disease]

Lipid domain microviscosity of human lipoproteins was investigated by means of pyrene eximerization measurements. In the case of hyperalphalipoproteinemias - antirisk factor of ischemic heart disease - the microviscosity of very low density lipoproteins (VLDL) decreases, and the microviscosity of high density lipoproteins increases; low density lipoproteins have a tendency to decrease the microviscosity. The VLDL microviscosity was found to decrease in a good correlation with the cholesterol loss in the lipoproteins. At the same time the quantity of plasma triglycerides increases. As VLDL have a greater part of plasma triglycerides it is suggested that with a decrease of VLDL microviscosity lipolysis of VLDL triglycerides increases.