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Lung compliance and its transient elevations measured with pulse-flow method

P M Suratt, D H Owens, H Hsiao

    Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology
    |June 1, 1981
    PubMed
    Summary
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    This study introduces a pulse-flow method for measuring lung compliance (CL), offering sensitivity to rapid CL changes. The method shows that increased lung compliance after deep breaths correlates with airway obstruction severity.

    Area of Science:

    • Pulmonary Physiology
    • Respiratory Mechanics Measurement

    Background:

    • Static lung compliance (CL) is a key respiratory parameter.
    • Traditional methods may not capture rapid CL transients.
    • A need exists for sensitive CL measurement techniques.

    Purpose of the Study:

    • To introduce and validate a novel pulse-flow method for measuring static lung compliance (CL).
    • To assess the sensitivity of the pulse-flow method to rapid CL transients.
    • To investigate the relationship between pulse CL, static CL, and airway obstruction.

    Main Methods:

    • A pulse-flow technique was employed, involving constant airflow inhalation for 2 seconds.
    • Lung compliance (CL) was calculated by dividing airflow (L/s) by the change in transpulmonary pressure (CMH2O/s).

    Related Experiment Videos

  • Pulse and static inspiratory CL were measured in healthy subjects and patients with obstructive lung diseases, obesity, and pulmonary fibrosis.

    • Main Results:

    • Pulse CL measurements after tidal breathing strongly correlated with static CL measured after deep breaths (r = 0.96).
    • Pulse CL after deep breaths was significantly higher than pulse CL after tidal breathing (p < 0.01) and static CL after deep breaths (p < 0.05).
    • A significant inverse relationship was found between forced expiratory volume in 1 second (FEV1/FVC) and the increase in pulse CL after a deep breath (r = 0.93), indicating a link to airway obstruction. The subsequent fall in pulse CL followed a 1/t2 decay rate.

    Conclusions:

    • The pulse-flow method is a sensitive technique for measuring static lung compliance (CL), capable of detecting rapid transients.
    • The increase in lung compliance following a deep breath is associated with the degree of airway obstruction.
    • The rate of decline in lung compliance after a deep breath is inversely proportional to the square of the time elapsed (1/t2).