Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement and glomerular disease - a natural history study

N P Mallick, K Eyres, E J Acheson

    Nephron
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Role of bovine chemokines produced by dendritic cells in respiratory syncytial virus-induced T cell proliferation.

    Veterinary immunology and immunopathology·2002
    Same author

    The natural history of developmental dysplasia of the hip after early supervised treatment in the Pavlik harness. A prospective, longitudinal follow-up.

    The Journal of bone and joint surgery. British volume·2002
    Same author

    Human papillomavirus absence predicts normal cervical histopathologic findings with abnormal papanicolaou smears: a study of a university-based inner city population.

    Journal of human virology·2002
    Same author

    Eliminating the issue of skin color in assessment of the blanch response.

    Advances in skin & wound care·2002
    Same author

    Characteristics of the first H-mode discharges in the national spherical torus experiment.

    Physical review letters·2002
    Same author

    Increased leaf area expansion of hybrid poplar in elevated CO2. From controlled environments to open-top chambers and to FACE.

    Environmental pollution (Barking, Essex : 1987)·2002
    Same journal

    The Impact of High-Altitude Acclimatization on Frontal Lobe Executive Function: The Mediating Effect of Creatinine.

    Nephron·2026
    Same journal

    Expert Commentary of the Recent International Pediatric Nephrology Association IgA Vasculitis Nephritis Guidelines.

    Nephron·2026
    Same journal

    Acute effects of exercise on the nephron index under different conditions in middle-aged males - a preliminary study.

    Nephron·2026
    Same journal

    Lysozyme-Associated Nephropathy in Myeloid Neoplasms: A Clinicopathological and Mass Spectrometric Study of Two Cases.

    Nephron·2026
    Same journal

    Prevalence of COVID-19 Pneumonia and Clinical Characteristics in Hemodialysis Patients During the SARS-CoV-2 Omicron Pandemic.

    Nephron·2026
    Same journal

    Real-World Outcomes of Patients with Monoclonal Gammopathy of Renal Significance.

    Nephron·2026
    See all related articles

    Primary abnormalities in the complement system may predispose patients to glomerular lesions. However, these complement defects did not impact patient prognosis in this study.

    Area of Science:

    • Nephrology
    • Immunology
    • Clinical Chemistry

    Background:

    • Glomerular lesions can be associated with complement system abnormalities.
    • Distinguishing primary complement defects from secondary changes is crucial for understanding disease pathogenesis.
    • The role of complement system abnormalities in the prognosis of glomerular diseases requires further investigation.

    Purpose of the Study:

    • To investigate the relationship between complement component levels and glomerular lesions.
    • To determine if primary complement defects influence disease prognosis.
    • To explore the utility of complement component profiling in classifying glomerular histopathology.

    Main Methods:

    • Sequential measurement of complement components in 127 patients with glomerular lesions over 5 years.

    Related Experiment Videos

  • Analysis of complement levels during active disease and remission phases.
  • Discriminant analysis of complement component levels to identify patterns and prognostic significance.

    • Main Results:

    • Persistent complement defects were observed in 17 patients without C3 nephritic factor, suggesting a primary predisposition to glomerular lesions.
    • In 12 other patients, complement levels normalized during remission, indicating secondary changes.
    • Discriminant analysis revealed that specific patterns of circulating complement components could distinguish histological subgroups and had prognostic value.

    Conclusions:

    • Primary complement system abnormalities may predispose individuals to glomerular lesions, though they may not affect prognosis.
    • Complement level dynamics during disease and remission can differentiate primary defects from secondary changes.
    • Computer-assisted analysis of complement component patterns offers valuable insights into glomerular disease classification and prognosis.