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Alcohol does not enhance diazepam absorption

M Divoll, D J Greenblatt

    Pharmacology
    |January 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Consuming alcohol with diazepam may slightly slow drug absorption but does not affect how much is absorbed or how quickly it is eliminated. This study examined diazepam and alcohol interactions in healthy volunteers.

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    Area of Science:

    • Pharmacology
    • Clinical Pharmacology
    • Drug Interactions

    Background:

    • Diazepam is a commonly prescribed benzodiazepine.
    • Alcohol is frequently consumed socially.
    • Understanding drug-alcohol interactions is crucial for patient safety.

    Purpose of the Study:

    • To investigate the effect of co-administering diazepam with a typical social alcoholic beverage on diazepam's pharmacokinetic profile.
    • To determine if alcohol influences the absorption rate, extent, and elimination of diazepam.

    Main Methods:

    • A randomized 3-way crossover study involving 6 healthy volunteers.
    • Administration of a single 5-mg oral dose of diazepam under three conditions: with water, with a vodka-water mixture, or with water after a vodka-water mixture.

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  • Measurement of plasma diazepam and desmethyldiazepam concentrations over time.

    • Main Results:

    • Peak plasma diazepam levels and time to peak concentration showed non-significant differences across conditions.
    • Total plasma concentration-time curves (AUC) and elimination half-life of diazepam were similar in all trials.
    • The rate and extent of desmethyldiazepam formation were not significantly affected by alcohol co-administration.

    Conclusions:

    • Coadministration of diazepam with or shortly after a typical social alcoholic drink may slightly delay the rate of diazepam absorption.
    • Alcohol consumption does not significantly alter the completeness of diazepam absorption or its elimination rate.
    • These findings suggest a limited impact of moderate alcohol intake on overall diazepam exposure.