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[Thyroid function after mantle field radiation therapy (author's transl)]

W Dähnert, J Kutzner, W Grimm

    Strahlentherapie
    |August 1, 1981
    PubMed
    Summary
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    Malignant lymphoma patients receiving mantle field radiation therapy showed a high incidence of thyroid dysfunction, including hypothyroidism. Regular thyroid screening with TSH measurement and palpation is recommended for early detection and management.

    Area of Science:

    • Endocrinology
    • Oncology
    • Radiation Oncology

    Context:

    • Malignant lymphoma patients treated with mantle field radiation therapy.
    • Radiation doses ranged from 30 to 50 Gy.
    • Thyroid function was assessed 34 to 92 months post-treatment.

    Purpose:

    • To evaluate the incidence of thyroid dysfunction after mantle field radiation therapy for malignant lymphoma.
    • To review and discuss discrepancies in reported hypothyroidism rates in the literature.
    • To recommend a screening protocol for thyroid abnormalities in irradiated patients.

    Summary:

    • One patient (2.1%) developed myxedema.
    • 20.8% had subclinical hypothyroidism.
    • 12.5% had latent hypothyroidism.

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  • Literature review revealed varied hypothyroidism incidence rates.

    • Impact:

    • Highlights the significant risk of hypothyroidism post-radiation therapy for lymphoma.
    • Emphasizes the need for long-term thyroid surveillance in these patients.
    • Recommends TSH measurement and thyroid palpation for cost-effective screening.