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Is urinary cholesterol determination a possible screening test for urological carcinomas?
Urological Research
|January 1, 1981
Summary
Urinary cholesterol testing is not recommended as a primary screening tool for urogenital carcinomas in the general population due to cost and low prevalence. However, it may be useful in specific high-risk groups.
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Urinary cholesterol determination has been proposed for diagnosing urogenital carcinomas.
- Its utility as a large-scale screening test remains unproven.
Purpose of the Study:
- To evaluate the effectiveness of urinary total cholesterol as a screening method for urogenital carcinomas in an unselected population.
Main Methods:
- A study involving 430 males and 545 females over 50 years old.
- Measurement of total urinary cholesterol, with values exceeding 5.1 mg/24 h considered positive.
Main Results:
- Positive results were found in 3% of males and 1.6% of females.
- Among males with elevated levels, 2 bladder and 1 kidney carcinomas were detected, alongside benign conditions.
Conclusions:
- Urinary cholesterol testing is not recommended as a primary screening test for urogenital carcinomas in unselected populations due to cost and low prevalence.
- The method may hold potential for screening preselected populations with a higher prevalence of these carcinomas.