[Polyene antibiotic solubilization by bile acid salts in aqueous solutions]

The process of solubilization of polyenic antibiotics, such as amphotericin B, mycoheptin, levorin and nystatin in aqueous solutions of sodium salts of bile acids: desoxycholic, cholic and dehydrocholic was studied. It was shown that amphotericin B and mycoheptin had the highest capacity for solubilization. No solubilization of the antibiotics was observed in the solutions of sodium dehydrocholate. Thermodynamic estimation of the solubilization process with sodium desoxycholate is presented.