[Neuronal secretory activity of the hypothalamic large-cell nuclei in rats with spontaneous hypertension]

The study was carried out in 24 male rats with spontaneous hypertension (SHR, Kyoto Wistar) and control Wistar rats aged 8 and 12 weeks with the objective of detecting the time of activation of large cell neurosecretory nuclei of the anterior hypothalamus in rats with spontaneous hypertension. The activity of neurons of the supraoptical and paraventricular nuclei was evaluated by two quantitative methods. One of them allows the study of distribution of neurosecretory cells by phases of synthesis in these nuclei in 8- and 12-week-old animals. Along with this morphometrical method, the average diameter of neurosecretory cells and their nuclei was determined after Gomori's staining with chromium-alumen hematoxylin. Spontaneously hypertensive and control normotensive rats by 12 weeks of development were found to have an enhanced function of neurosecretory nuclei apparently associated with the age change in their functional activity. In spontaneously hypertensive rats, more pronounced activation of the supraoptic and paraventricular nuclei manifested by hypertrophy of neurons and their nuclei occurs only with the development of hypertension and is absent in the pre-hypertensive stage.