Radioruthenium -- 2,3-Dimercaptopropansulfonic acid complex. A potentially useful radiocompound for kidney studies

Radioruthenium complexed with 2,3-dimercaptopropansulfonic acid (DMPSA) shows a preferential localization in kidneys. After studying several parameters with regard to their influence on renal incorporation, the optimal procedure was established, showing an uptake by kidney (for 97Ru-labelled compound) of 30.3% dose/g/24 h or 43.4% dose/organ/24 h. The highest accumulation was reached 7-10 h after iv injection and no significant elimination was observed 24 h thereafter. The probable mechanisms involved in this process are discussed.