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Related Experiment Videos

Pseudorabies in a dog

L G Shell, R W Ely, R A Crandell

    Journal of the American Veterinary Medical Association
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Pseudorabies virus, a pathogen typically found in pigs, was diagnosed in a dog presenting with neurological and gastrointestinal signs. Histopathology revealed characteristic viral inclusions and inflammation in the brain stem, confirming the diagnosis.

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    Area of Science:

    • Veterinary Pathology
    • Virology
    • Canine Infectious Diseases

    Background:

    • Pseudorabies virus (PRV) is an alphaherpesvirus primarily affecting swine.
    • While PRV is endemic in swine populations, spillover to other species, including dogs, is rare but possible.
    • Understanding PRV pathogenesis in non-swine hosts is crucial for disease surveillance and control.

    Observation:

    • A 5-year-old crossbred dog presented with clinical signs including depression, hypersalivation, head pressing, and vomiting.
    • No gross pathological findings were observed.
    • Histological examination of the brain stem revealed significant findings.

    Findings:

    • Microscopic examination of the brain stem showed mononuclear cell infiltrates, perivascular cuffing, gliosis, neuronal degeneration, and characteristic acidophilic intranuclear inclusions in neurons and astrocytes.

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  • Edema in the lungs and fatty changes in the liver were also noted.
  • Virus isolation from the dog's brain and tonsils confirmed the presence of Pseudorabies virus, identified via fluorescent antibody technique.

    • Implications:

    • This case highlights the potential for Pseudorabies virus to cause severe neurological disease in domestic dogs.
    • The findings underscore the importance of considering PRV in the differential diagnosis of neurological conditions in dogs, especially in areas with active swine infections.
    • Effective biosecurity measures on farms are critical to prevent PRV transmission to non-target species and protect animal health.