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Intestinal absorption-partition relationships: a tentative functional nonlinear model

J M Plá-Delfina, J Moreno

Journal of Pharmacokinetics and Biopharmaceutics

|April 1, 1981

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This study reviews models of passive intestinal absorption, proposing a new model that incorporates pore transport for smaller molecules. This unified model explains previously contradictory absorption-partition data.

Area of Science:

Pharmacokinetics
Physical Chemistry
Biophysical Chemistry

Background:

Passive intestinal absorption is crucial for drug bioavailability.
Existing models often predict sigmoidal, hyperbolic, parabolic, or bilinear relationships between absorption rate constant (ka) and partition coefficients (P).
These models struggle to reconcile diverse experimental data, particularly for compounds of varying molecular weights.

Purpose of the Study:

To review existing models of passive intestinal absorption.
To propose a novel, unified model that reconciles contradictory absorption-partition data.
To investigate the role of pore transport in intestinal absorption.

Main Methods:

Analysis of the relationship between absorption rate constant (ka) and partition coefficients (P).

Related Experiment Videos

Review of classical nonlinear physical models (nonstirred layer, equilibrium extraction).

Development of an alternative model incorporating the Wagner-Sedman equilibrium extraction model and pore transport.

Main Results:

Classical models predict distinct relationships (sigmoidal, hyperbolic, parabolic, bilinear) between ka and P.
The proposed model integrates equilibrium extraction with pore transport for compounds < 250 Da.
The new model demonstrates high consistency with previously contradictory absorption-partition literature data.

Conclusions:

The proposed model offers a more comprehensive explanation for passive intestinal absorption mechanisms.
Pore transport is a significant factor for the absorption of low molecular weight compounds.
This unified approach enhances the understanding of drug absorption and disposition.