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Renal functions in lepromatous leprosy patients
Leprosy in India
|July 1, 1981
Summary
Kidney function, including urine acidification and filtration, is impaired in untreated lepromatous leprosy (LL) patients. These kidney issues worsen during lepra reactions, indicating significant renal involvement.
Area of Science:
- Nephrology
- Infectious Diseases
- Immunology
Background:
- Leprosy, particularly lepromatous leprosy (LL), can lead to secondary kidney involvement.
- Lepra reactions exacerbate renal complications in leprosy patients.
Purpose of the Study:
- To assess kidney function in lepromatous leprosy patients.
- To investigate parameters such as urine acidification, glomerular filtration rate (GFR), and dye excretion.
Main Methods:
- Evaluation of urine acidification capacity.
- Measurement of glomerular filtration rate (GFR).
- Assessment of foreign dye excretion after intramuscular administration.
Main Results:
- Untreated LL patients showed reduced urine acidification ability.
- A decrease in GFR was observed in untreated LL patients.
- Impaired dye excretion and reduced GFR were more severe during lepra reactions.
Conclusions:
- Lepromatous leprosy significantly impacts kidney function.
- Kidney dysfunction is more pronounced during lepra reactions, necessitating close monitoring.