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[Antirheumatic treatment in old age and its effect on kidney function]
Medizinische Klinik
|August 14, 1981
Summary
Piroxicam effectively treated osteoarthritis pain and stiffness in geriatric patients, even those with impaired renal function. The drug demonstrated good toleration and did not negatively impact kidney function or accumulate in patients with renal insufficiency.
Area of Science:
- Geriatric Medicine
- Pharmacology
- Nephrology
Context:
- Osteoarthritis is a prevalent degenerative joint disease, particularly affecting the geriatric population.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) like piroxicam are commonly used for osteoarthritis management.
- Renal function is a critical consideration in elderly patients, especially those with pre-existing renal insufficiency.
Purpose:
- To evaluate the efficacy and toleration of piroxicam in geriatric patients with osteoarthritis.
- To specifically assess the impact of piroxicam on renal parameters in patients with normal and impaired renal function.
- To determine piroxicam plasma levels in patients with renal insufficiency.
Summary:
- Piroxicam treatment improved pain and joint mobility in both geriatric patients with normal and impaired renal function.
- No significant changes in laboratory values were observed in patients with normal renal function.
- Renal parameters showed potential improvement in patients with renal insufficiency, with no drug accumulation observed.
Impact:
- Piroxicam offers a safe and effective treatment option for osteoarthritis in geriatric patients, including those with compromised renal function.
- The study suggests piroxicam may have a neutral or even beneficial effect on renal parameters in patients with renal insufficiency.
- These findings support the use of piroxicam in a broader geriatric patient population, easing concerns about renal safety.