Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Knee function after intra-articular hydrocortisone

D H Bossingham, A K McQueen, A G Mowat

    Rheumatology and Rehabilitation
    |May 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Specificity of T cells in synovial fluid: high frequencies of CD8(+) T cells that are specific for certain viral epitopes.

    Arthritis research·2000
    Same author

    Surgery for rheumatoid arthritis of the elbow: a comparison of radial-head excision and synovectomy with total elbow replacement.

    Journal of shoulder and elbow surgery·1999
    Same author

    Synovectomy of the elbow and radial head excision in rheumatoid arthritis. Predictive factors and long-term outcome.

    The Journal of bone and joint surgery. British volume·1997
    Same author

    Acute laryngeal obstruction in rheumatoid arthritis.

    BMJ (Clinical research ed.)·1996
    Same author

    Lupus-like syndrome in patients treated for acne.

    British journal of rheumatology·1995
    Same author

    Arthrotec in general practice. Proceedings from the clinical investigator meeting held May 1994, Leeds, UK.

    European journal of rheumatology and inflammation·1994
    Same journal

    Parenteral iron therapy in the anaemia of rheumatoid arthritis.

    Rheumatology and rehabilitation·1982
    Same journal

    Diclofenac sodium, diflunisal and naproxen: patient preferences for anti-inflammatory drugs in rheumatoid arthritis.

    Rheumatology and rehabilitation·1982
    Same journal

    Polymyalgia rheumatica in a defined elderly community.

    Rheumatology and rehabilitation·1982
    Same journal

    The recovery of the severely disable stroke patient.

    Rheumatology and rehabilitation·1982
    Same journal

    Multisystem presentation of eosinophilic fasciitis.

    Rheumatology and rehabilitation·1982
    Same journal

    Group G streptococcal arthritis.

    Rheumatology and rehabilitation·1982
    See all related articles

    Intra-articular hydrocortisone significantly improved knee flexion in rheumatoid synovitis patients for eight weeks. Functional improvements lagged behind pain relief, impacting drug assessment strategies.

    Area of Science:

    • Rheumatology
    • Orthopedics
    • Pharmacology

    Background:

    • Rheumatoid synovitis causes significant knee joint dysfunction and pain.
    • Intra-articular corticosteroid injections are a common treatment modality.
    • Objective assessment of treatment efficacy is crucial for patient management.

    Purpose of the Study:

    • To objectively assess the effect of intra-articular hydrocortisone on knee function in rheumatoid synovitis.
    • To compare the efficacy of hydrocortisone against intra-articular saline injections.
    • To evaluate the time course of functional and symptomatic improvement.

    Main Methods:

    • A single-blind study involving 12 patients with rheumatoid synovitis.
    • Objective assessment of knee flexion range during walking using an electrogoniometer.

    Related Experiment Videos

  • Comparison of hydrocortisone injections with intra-articular saline placebo.

    • Main Results:

    • Intra-articular hydrocortisone significantly improved knee flexion range, with some patients achieving normal levels.
    • The beneficial effects on knee flexion were maintained for up to eight weeks.
    • Functional improvements were observed to occur more slowly than pain relief.

    Conclusions:

    • Intra-articular hydrocortisone provides significant symptomatic and functional benefits for knees affected by rheumatoid synovitis.
    • The differential rate of improvement in pain versus function has implications for anti-inflammatory drug evaluation.
    • Electrogoniometry offers an objective method for assessing treatment outcomes in inflammatory arthritis.