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Allogeneic antibody response in cattle

M J Newman, M R Brandon

    American Journal of Veterinary Research
    |June 1, 1981
    PubMed
    Summary
    This summary is machine-generated.

    Heifers developed antibody responses to goose red blood cells (GRBC) and allogeneic lymphocytes, but not ovalbumin. Lymphocyte antibody responses were predominantly IgM and varied between animals.

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    Area of Science:

    • Immunology
    • Veterinary Science

    Background:

    • Understanding immune responses in cattle is crucial for vaccine development and disease management.
    • Bovine immune system complexity requires detailed study of antibody production against various antigens.

    Purpose of the Study:

    • To investigate antibody production in heifers following immunization with allogeneic bovine lymphocytes, goose red blood cells (GRBC), and ovalbumin.
    • To characterize the nature and kinetics of antibody responses, including immunoglobulin classes and cytotoxic activity.

    Main Methods:

    • Twenty heifers were immunized with allogeneic lymphocytes, GRBC, and ovalbumin.
    • Antibody titers were measured over time using serological assays.
    • Cytotoxic assays were employed to detect antibodies against lymphocytes.

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    Main Results:

    • Antibodies to GRBC showed a typical primary IgM and secondary IgG response.
    • Ovalbumin failed to induce a detectable antibody response.
    • Low-titer, predominantly IgM antibody responses to allogeneic lymphocytes were observed, with variable onset.
    • Cytotoxic antibodies recognized B and T lymphocytes, likely targeting BoLA antigens.

    Conclusions:

    • Heifers exhibit distinct antibody responses to different antigens, with GRBC eliciting a robust response and lymphocytes a weaker, IgM-dominant one.
    • The immune response to allogeneic lymphocytes is complex and not solely dependent on major histocompatibility complex differences.
    • Further research is needed to fully elucidate the targets of bovine alloantibodies.