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Changes in serum ferritin levels after intravenous iron
Annals of Clinical Biochemistry
|July 1, 1981
Summary
Intravenous iron dextran effectively raises serum ferritin in iron deficiency anemia patients. Peak levels occur 7-9 days post-infusion, correlating with cellular non-haem iron.
Area of Science:
- Hematology
- Biochemistry
Background:
- Iron deficiency anemia is a common condition requiring effective treatment.
- Intravenous iron dextran is a therapeutic option for severe iron deficiency.
Observation:
- Two patients with iron deficiency anemia received intravenous iron dextran.
- Serum ferritin levels and plasma iron were monitored post-infusion.
Findings:
- Serum ferritin levels increased significantly, peaking 7-9 days after iron dextran infusion.
- A linear relationship was observed between log serum ferritin and log cellular non-haem iron levels.
- Over 90% of infused iron was cleared from plasma before peak ferritin levels were reached.
Implications:
- Intravenous iron dextran is an effective method for increasing serum ferritin.
- The findings provide insight into iron metabolism and ferritin kinetics following iron therapy.
- This data may inform optimal timing for monitoring iron repletion in anemic patients.
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