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[Pulmonary lymphoid follicles and lymph nodes in the dynamics of chronic pulmonary diseases]
Comparative studies of 532 necropsy, operation, and biopsy materials from different chronic pulmonary diseases demonstrated massive new formation of lymphoid follicles with an increase in their total volume 500-fold or more in chronic pneumonia. The newly formed lymphoid follicles comprise a significant but only temporary supplement of the immunocompetent tissue of the affected lungs. As the inflammation wanes, the newly formed intrapulmonary follicles disappear gradually. Immunodeficient diseases are usually not accompanied by formation of new lymphoid follicles. As results of these observations can be applied to chronic organ pathology as a whole, a concept of mobile lymphoid cell reserve of the immune system may be justified.
Comparative studies of 532 necropsy, operation, and biopsy materials from different chronic pulmonary diseases demonstrated massive new formation of lymphoid follicles with an increase in their total volume 500-fold or more in chronic pneumonia. The newly formed lymphoid follicles comprise a significant but only temporary supplement of the immunocompetent tissue of the affected lungs. As the inflammation wanes, the newly formed intrapulmonary follicles disappear gradually. Immunodeficient diseases are usually not accompanied by formation of new lymphoid follicles. As results of these observations can be applied to chronic organ pathology as a whole, a concept of mobile lymphoid cell reserve of the immune system may be justified.