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Neonatal candidosis, a fungal sepsis, frequently affects premature infants, often involving the brain and internal organs. Infection can occur before, during, or after birth, with tissue reactions indicating its nature.
Area of Science:
- Medical Mycology
- Neonatal Pathology
- Infectious Diseases
Context:
- Presents morphological observations of 11 neonatal candidosis cases.
- Highlights candidosis as a form of sepsis in newborns.
- Notes the high incidence in premature and underdeveloped infants.
Purpose:
- To describe the pathological course and presentation of candidosis in neonates.
- To identify routes of neonatal Candida infection.
- To emphasize the diagnostic role of tissue reactions.
Summary:
- Neonatal candidosis manifests as sepsis, predominantly affecting the brain, or both brain and internal organs.
- The condition is particularly severe in premature and underdeveloped infants.
- Infection acquisition occurs in utero, during passage through the birth canal, or postnatally.
- Diagnosis relies on observing tissue responses to Candida.
Impact:
- Informs understanding of neonatal fungal infections.
- Aids in early diagnosis and management strategies for candidosis.
- Underscores the vulnerability of premature infants to invasive fungal infections.
Abstract:
Morphological observations of 11 cases of candidosis in newborn infants are presented. Candidosis runs the course of sepsis either with predominant involvement of the brain or with involvement of the brain and internal organs. The process was well-defined in underdeveloped babies and occurrred in all prematurely born babies. The babies could contract the infection in the three ways; in utero, in the course of passing the genital tract, or immediately after the delivery. The nature of the infection can be determined only on the basis of tissue reactions developing in response to Candida vegetation.