Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Ultrastructure of human chromosomes]

H G Schwarzacher

    Bulletin Der Schweizerischen Akademie Der Medizinischen Wissenschaften
    |November 1, 1978
    PubMed
    Summary

    Chromosomes are composed of DNA double-helix fibrils. Chromosome banding patterns are influenced by DNA base composition (AT and GC content) and chromosome structure during cell division.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Ribosome biogenesis in man: current views on nucleolar structures and function.

    Cytogenetics and cell genetics·2001
    Same author

    The nucleolus.

    Anatomy and embryology·1993
    Same author

    Nucleolar morphology and rDNA in situ hybridisation in monocytes.

    Cell and tissue research·1992
    Same author

    Human ribosomal RNA gene repeats are localized in the dense fibrillar component of nucleoli: light and electron microscopic in situ hybridization in human Sertoli cells.

    Experimental cell research·1992
    Same author

    Nucleoli, nucleolar chromosomes and ribosomal genes in the human spermatocyte.

    Chromosoma·1991
    Same author

    Transcribed and nontranscribed parts of the human ribosomal gene repeat show a similar pattern of distribution in nucleoli.

    Cytogenetics and cell genetics·1991

    Area of Science:

    • Molecular Biology
    • Cell Biology
    • Genetics

    Context:

    • Chromosomes are the fundamental structures carrying genetic information in eukaryotic cells.
    • Understanding chromosome structure is crucial for comprehending cell division and genetic inheritance.
    • The organization of DNA into chromatin fibrils dictates chromosome morphology and function.

    Purpose:

    • To describe the structural organization of eukaryotic chromosomes.
    • To explain the formation of chromosomes during different stages of the cell cycle (interphase, prophase, metaphase).
    • To elucidate the factors contributing to chromosome banding, including DNA base composition.

    Summary:

    • Eukaryotic chromosomes are primarily composed of single chromatin fibrils, each containing one DNA double helix.
    • During mitosis, chromatin fibrils condense and coil to form visible chromosomes, with distinct structures in prophase and metaphase.
    • Chromosome banding, observable through staining techniques, is significantly influenced by the varying AT and GC content within specific chromosomal regions.

    Impact:

    • Provides foundational knowledge on chromosome structure and organization.
    • Highlights the relationship between DNA composition and chromosome morphology.
    • Contributes to the understanding of cytogenetics and the basis of chromosome banding patterns.

    Related Experiment Videos