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[Modification of urinary pH through ascorbic acid]

C Bannwart, V Hagmaier, E Straumann

Helvetica Chirurgica Acta

|August 1, 1981

Summary

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Oral vitamin C (ascorbic acid) minimally impacts urinary pH in healthy individuals and those with infected urine. The study found it ineffective for lowering alkaline urine pH, suggesting it cannot be recommended for this purpose.

Area of Science:

Biochemistry
Urology
Nutritional Science

Context:

Investigating the metabolic effects of vitamin C supplementation.
Assessing urinary pH modulation in clinical and healthy populations.
Understanding the relationship between ascorbic acid intake and urine chemistry.

Purpose:

To determine the efficacy of orally administered ascorbic acid in altering urinary pH.
To evaluate the dose-dependent relationship between ascorbic acid concentration and urinary pH changes.
To assess the potential of vitamin C as a therapeutic agent for managing alkaline urine.

Summary:

A four-day study involving 10 healthy volunteers and 10 patients with infected urine measured urinary pH and ascorbic acid levels.
Participants received 2g of ascorbic acid three times daily on days two and three, with controlled diets.

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A significant correlation between pH decrease and ascorbic acid concentration was observed only when concentrations exceeded 200 mg%. The mean urinary pH decrease was minimal (-0.16 to -0.18 pH units), indicating limited efficacy.

Impact:

Provides evidence against the use of vitamin C for lowering alkaline urine pH.
Contributes to understanding the physiological limits of ascorbic acid's effect on urine acidity.
Informs clinical practice regarding the management of urine pH and the limitations of vitamin C supplementation.