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Related Experiment Videos

Ethanol reinforced behavior assessed with a concurrent schedule

T A Roehrs, H H Samson

    Pharmacology, Biochemistry, and Behavior
    |October 1, 1981
    PubMed
    Summary

    Rats developed a strong preference for oral ethanol (5% v/v) over water, even at high fixed ratio (FR) requirements. This indicates ethanol

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    Area of Science:

    • Behavioral neuroscience
    • Pharmacology
    • Animal models

    Background:

    • Ethanol self-administration is a key area of addiction research.
    • Understanding factors influencing ethanol consumption is crucial for developing effective interventions.

    Purpose of the Study:

    • To investigate ethanol (5% v/v) reinforced responding in rats under a concurrent schedule of reinforcement.
    • To assess the development and maintenance of ethanol preference over water.

    Main Methods:

    • Rats were trained on a concurrent fixed ratio (FR) schedule for water and ethanol access.
    • Ethanol intake and responding patterns were monitored as FR requirements were manipulated.
    • Blood ethanol levels were measured to assess intoxication levels.

    Main Results:

    • Rats rapidly developed robust ethanol-reinforced responding, exceeding water responding by 11 times.
    • Ethanol preference persisted even when the ethanol FR requirement was significantly increased (up to FR50).
    • Some rats achieved blood ethanol levels between 30-50 mg/100 ml within sessions.

    Conclusions:

    • Oral ethanol is a potent reinforcer in rats, capable of maintaining high levels of responding.
    • Ethanol preference can be robustly established and maintained against a concurrent water source.
    • These findings provide a valuable animal model for studying the determinants of ethanol consumption.

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