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Abstract:
Cadmium chloride (CdCl2) was injected s.c., 1.5 mg Cd/kg body weight into female Wistar rats for 7 consecutive days. Liver tissue was subfractionated, and ca. 2% of Cd in the tissue was found in the mitochondria and lysosomes, respectively. A high proportion of Cd, in the solubilized mitochondria and lysosomes, was bound to metallothionein and a small amount was distributed to higher molecular weight fraction. Cd in liver mitochondria and lysosomes exists mainly in the form of metallothionein.