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Related Experiment Videos

Fatal echovirus type 11 infections

N Halfon, S A Spector

    American Journal of Diseases of Children (1960)
    |November 1, 1981
    PubMed
    Summary

    Fatal echovirus type 11 infections in infants can cause disseminated intravascular coagulation and organ necrosis. A unique case presented with focal myositis beyond the neonatal period.

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    Area of Science:

    • Pediatric Infectious Diseases
    • Virology
    • Pathology

    Background:

    • Echovirus type 11 (EV-11) infections can lead to severe outcomes in infants.
    • Understanding the clinical spectrum and pathological findings of EV-11 is crucial for diagnosis and management.

    Observation:

    • Two infants presented with fatal EV-11 infections, exhibiting disseminated intravascular coagulation (DIC).
    • Postmortem examinations revealed diffuse hemorrhagic necrosis across multiple organ systems, particularly the liver.
    • A distinct case involved a 3-month-old infant with lethargy, vomiting, occipital scalp/neck edema, and diffuse EV-11 disease, including focal myositis.

    Findings:

    • The observed focal myositis in the 3-month-old infant is a unique clinical manifestation of EV-11 disease.
    • This case represents the first documented nonparalytic, fatal EV-11 infection occurring outside the immediate neonatal period.
    • DIC and hemorrhagic necrosis are significant pathological findings associated with severe EV-11 infection.

    Implications:

    • These findings highlight the potential severity and varied presentations of EV-11 in infants.
    • Early recognition of EV-11 symptoms and prompt diagnostic evaluation are critical.
    • Further research into EV-11 pathogenesis and treatment strategies is warranted.

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