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Cephradine levels in human aqueous humor
Archives of Ophthalmology (Chicago, Ill. : 1960)
|November 1, 1981
Summary
Oral cephradine effectively penetrates the aqueous humor in humans, reaching concentrations above the minimum inhibitory concentration for common pathogens like Streptococcus pneumoniae and Staphylococcus aureus.
Area of Science:
- Ophthalmology
- Pharmacology
- Infectious Diseases
Background:
- Cephradine is a first-generation cephalosporin antibiotic.
- Understanding antibiotic penetration into ocular tissues is crucial for treating eye infections.
Purpose of the Study:
- To investigate the penetration of orally administered cephradine into the primary aqueous humor in humans.
- To determine the aqueous humor concentrations achieved with different oral doses of cephradine.
Main Methods:
- Oral administration of 500-mg and 1-g doses of cephradine to 27 patients undergoing cataract surgery.
- Measurement of cephradine levels in aqueous humor samples collected at approximately three hours post-administration.
Main Results:
- A mean peak aqueous humor concentration of 0.87 µg/mL was achieved with the 500-mg dose.
- A mean peak aqueous humor concentration of 1.99 µg/mL (range 0.91–3.25 µg/mL) was achieved with the 1-g dose.
- Achieved concentrations exceeded the median minimum inhibitory concentration (MIC) for Streptococcus pneumoniae, Streptococcus pyogenes, and Staphylococcus aureus.
Conclusions:
- Oral cephradine demonstrates significant penetration into the human aqueous humor.
- The achieved concentrations suggest potential efficacy against certain ocular pathogens, particularly Streptococcus pyogenes.