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Abstract:
A model has been constructed of an assembly of mammalian epidermal cells. The model, simulated by computer, has served as a framework by which experiments can be performed "in machina". Relationships between the various parameters considered have been established. Hypotheses referring to the time at which cells leave the basal layer, and to the simultaneous occurrence of folded basal layer and of a significant number of vertical mitosis in some hyperplastic conditions have been implemented and examined.