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Renin substrate in rat mesenteric artery

S Desjardins-Giasson, J Gutkowska, R Garcia

    Canadian Journal of Physiology and Pharmacology
    |June 1, 1981
    PubMed
    Summary
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    Bilateral nephrectomy significantly increased renin substrate (RS) in rat plasma and arteries. Adrenalectomy decreased RS, with greater impact on arterial tissue, suggesting local angiotensin II generation in resistance vessels.

    Area of Science:

    • Physiology
    • Renal Physiology
    • Vascular Physiology

    Background:

    • Renin substrate (RS) is a key component of the renin-angiotensin system (RAS).
    • The presence and regulation of RS in arterial tissue are not fully understood.
    • Local generation of angiotensin II within blood vessels may play a significant role in regulating vascular tone.

    Purpose of the Study:

    • To investigate the concentration and regulation of renin substrate (RS) in rat mesenteric artery tissue.
    • To compare RS levels in arterial tissue and plasma following nephrectomy and adrenalectomy.
    • To assess the potential for local angiotensin II generation in resistance vessels.

    Main Methods:

    • Measurement of renin substrate (RS) concentration in rat mesenteric artery tissue and plasma.

    Related Experiment Videos

  • Experimental groups included bilateral nephrectomy, adrenalectomy, and sham-operated controls.
  • Analysis of RS concentration changes at different time points post-surgery.

    • Main Results:

    • Bilateral nephrectomy markedly increased RS in both plasma and arterial tissue compared to controls, with a greater percentage increase in plasma.
    • Adrenalectomy decreased RS, with a more pronounced reduction in arterial tissue than in plasma.
    • Sham operations induced transient changes in RS levels in both plasma and arterial tissue.
    • A positive correlation was observed between arterial and plasma RS concentrations overall, but not within specific experimental groups.

    Conclusions:

    • Renal and adrenal status significantly influences renin substrate (RS) levels in both plasma and arterial tissue.
    • The findings suggest that the necessary components for local angiotensin II generation are present within the walls of resistance vessels.
    • This highlights the potential for intra-arterial RAS activity in regulating vascular function.