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Aminophylline in ureterolithiasis: preliminary report
International Journal of Clinical Pharmacology, Therapy, and Toxicology
|November 1, 1981
Summary
Aminophylline provided pain relief for ureter stone patients, with higher serum levels correlating to better results. Further studies are needed due to the short duration of pain reduction after a single injection.
Area of Science:
- Pharmacology
- Nephrology
- Pain Management
Background:
- Ureter stones commonly cause severe colicky pain.
- Effective pain management for ureteric colic is crucial.
- Theophylline derivatives, like aminophylline, have potential smooth muscle relaxant properties.
Purpose of the Study:
- To evaluate the efficacy of aminophylline in managing pain associated with ureter stones.
- To determine the relationship between serum aminophylline levels and pain relief.
Main Methods:
- Six patients with ureter stone-induced colicky pain received intravenous aminophylline (3 mg/kg).
- Pain reduction was subjectively assessed.
- Serum aminophylline levels were monitored.
Main Results:
- Five out of six patients experienced a prompt and significant decrease in pain.
- Pain relief lasted between 30 minutes and 2 hours.
- Serum aminophylline levels exceeding 12 microgram/ml were associated with effective pain relief.
Conclusions:
- Aminophylline demonstrates potential as an analgesic for ureteric colic.
- The short duration of action necessitates further investigation.
- A controlled study using intravenous aminophylline infusion is recommended to confirm efficacy and optimize treatment protocols.